Coagulopathy characterizing COVID-19
The unique characteristics of COVID-19 coagulopathy, Critical Care 2020; 24: 360;
IL-6 and central cytokine storms are not characteristic for COVID-19
Severe COVID-19 Infections- Knowledge gained and remaining questions, JAMA Internal Medicine, 18 September 2020;
Immune profile
Doctors may have found a new way to predict and treat severe coronavirus cases (IL-7 to treat severe COVID-19), BGR Science, May 31, 2020;
Pathogenesis and viral tropism of SARS-Coronaviruses
Role of SARS-CoV Viroporins E, 3a and 8a in Replication and Pathogenesis, mBio 2018 May-Jun; 9(3);
Secondary structure of the SARS-CoV-2 5'-UTR, RNA Biology 2020:1-10;
SARS-CoV-2 uses a second doorway into cells: Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity, Science 20 October 2020;
The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds, Antiviral Research 2015 Mar;115:21-38;
Molecular epidemiology, evolution and phylogeny of SARS-coronavirus, Infection, Genetics and Evolution 2019 Jul;71:21-30;
SARS-CoV-2 ORF3b is a Potent Interferon Antagonist whose activity is increased by a naturally occurring elongation variant, Cell Reports 2020 Sep 22;32(12);
Cardiovascular Implications of Fatal Outcomes of Patients with COVID-19, JAMA Cardiology 2020 Jul; 5(7): 1-8;
Outcomes of Cardiovascular MRI in Patients Recently discovered from COVID-19, JAMA Cardiology 2020, 27 July 2020;
Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo, Cell discovery 2020;6:76;
Lung tissue in fatal COVID-19 shows broad cell tropism and extensive damage, News Medical Life Sciences, September 30, 2020;
The Natural History, Pathobiology and Clinical Manifestations of SARS-CoV-2 Infections, Journal of Neuroimmune Pharmacology 2020 Jul 21: 1-28;
The PDZ-Binding Motif of SARS-Coronavirus envelope protein is a determinant of viral pathogenesis, PLoS Pathogens 2014 Aug; 10(8);
In silico identification of Tretinoin as a SARS-CoV-2 envelope (E) protein ion channel inhibitor, Computers in Biology and Medicine 2020 Dec; 127: 104063;
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC, eLife Sciences 2020;9;
Dying with SARS-CoV-2 infection-- an autopsy study of the first consecutive 80 cases in Hamburg, Germany, International Journal of Legal Medicine 2020 Jun 4: 1-10;
Possible treatment options for COVID-19
Kallikrein-kinin blockade in patients with COVID-19 to prevent Acute Respiratory Syndrome, eLife 2020; 9;
Mechanisms of Protective Effects of SGLT2 Inhibitors in Cardiovascular Disease and Renal Dysfunction, Current topics in medicinal chemistry 2019;19(20): 1818-1849;
Outcomes Associated with use of a Kinin B2 Receptor Antagonist among patients with COVID-19, JAMA Infectious Diseases 2020;3(8);
Abelson Kinase Inhibitors Are Potent Inhibitors of SARS-CoV and MERS-CoV Fusion, Journal of Virology 2016 Oct 1; 90(19):8924-8933;
Salvia miltiorrhiza Injection alleviates LPS-induced Acute Lung Injury by adjusting the balance of MMPs/TIMPs ratio, Evidence Based Complement Alternative Medicine 2020;2020;
Sonic Hedgehog Signaling: Evidence for its Protective Role in Endotoxin Induced ALI in mouse model, PLoS One 2015; 10(11);
Extracorporeal membrane oxygenation for SARS associated with COVID-19: a retrospective cohort study, Lancet Respiratory Medicine Vol. 8, Issue 11, November 01, 2020;
Novel hybrid antiviral VTRRT-13V2.1 against SARS-CoV-2 main protease: retro-combinatorial synthesis and molecular dynamics analysis, Heliyon Vol. 6, Issue 10, October 2020;
A perspective on Erythropoietin as a potential adjuvant therapy for ALI/ARDS in patients with COVID-19, Archives of Medical Research 2020 Aug 11;
Association between chronic ACE receptor inhibitor exposure and decreased odds of severe disease in patients with COVID-19, Anatolian Journal of Cardiology 2020; 24(1): 21-29;
Vorolanib and everolimus: Lenvatinib and everolimus part deux, or something new?, EBioMedicine Vol. 56, June 2020;
MMP-8 Inactivates Macrophage Inflammatory Protein-1alpha to Reduce Acute Lung Inflammation and Injury in Mice, Journal of Immunology 2010 Feb 1;184(3): 1575-1588;
Sofosbuvir for COVID-19 infection: a potential candidate, Indian Journal of Pharmacology 2020 May-Jun; 52(3): 232-233;
Broad spectrum coronavirus antiviral drug discovery, Expert Opin Drug Discovery 2019; 14(4): 397-412;
Apirin
Use is Associated with Decreased Mechanical Ventilation, ICU Admission,
and In-Hospital Mortality in Hospitalized Patients with COVID-19, Anesthesia & Analgesia: October 21, 2020;
Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19?, Drugs 80, 1383-1396(2020);
Ac2-26 mimetic peptide of annexin A1 to treat severe COVID-19: A hyptothesis, Medical Hypotheses 2020 Dec; 145: 110352;
Umbilical cord: an allogenic tissue for potential treatment of COVID-19,
Ebselen, Disulfirum, Carmofur, PX-12, Tideglusib and Shikonin are nonspecific promiscious SARS-CoV-2 main protease inhibitors, ACS Pharmacological Translational Sciences 2020 Oct 9;
Preprints (warning: never draw conclusions based on MedRxiv and BioRxiv research papers: preprints from the Rxiv server still have to undergo peer review, conclusions are preliminary and might turn out to be invalid)
Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models, October 28, 2020;
A neutrophil activation signature predicts critical illness and mortality in COVID-19, September 02, 2020;
