 |
| Factors involved in SARS-CoV-2/COVID-19 |
Activated endothelium as a source of Acute Lung Injury (ALI)/ARDS
Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients, BMJ Thorax Journal Vol 63, Issue 10, October 2008;
Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS, Pulmonary Circulation 2018 Apr-Jun; 8(2);
Acute Lung Injury (ALI)
A Perspective on Erythropoietin as a Potential Adjuvant Therapy for Acute Lung Injury (ALI)/ARDS in Patients with COVID-19, Archives of Medical Research 2020, Aug 11;
Coagulation
Thromboinflammation and the hypercoagulability of COVID-19, Journal of Thrombosis and Haemostasis, 13 April 2020;
Embolism
Pulmonary embolism in COVID-19 patients: a French multicentre cohort study, European Heart Journal Vol. 41, Issue 32, 21 August 2020, p3058-3068;
Hypoxia and HIF as a link between sepsis and thrombosis
Hypoxia and HIF activation as a possible link between sepsis and thrombosis, Thrombosis Journal 2019; 17: 16;
The stimulation of thrombosis by hypoxia, Thrombosis Research Vol. 181, p77-83, September 01, 2019;
Hypoxia response and acute lung and kidney injury: possible implications for therapy of COVID-19, Clinical Kidney Journal 2020 Aug; 13(4): 494-499;
Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage, Clinical and Experimental Immunology, Journal of Translational Immunology, 26 September 2020;
COVID-19: hemoglobin, iron and hypoxia beyond inflammation: A narrative review, Clinics and Practice 2020 May 19; 10(2): 1271;
miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target, Angiogenesis 2018; 21(2): 183-202;
Hypoxia and Reactive Oxygen Species (ROS) (oxidative stress)
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia, Journal of Molecular Medicine 2007 Dec;85(12):1309-15;
Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema (curcumin as a NFkB blocker attenuates hypoxia-induced edema), Experimental Biology and Medicine Vol. 233, Issue 9, 2008;
Pathogenesis and structure of SARS-CoV-2
Does the pathogenesis of SARS-CoV-2 decrease at high-altitude?, Respiratory Physiology & Neurobiology Vol. 277, June 2020;
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein, MDPI Viruses 2012 Jun;4(6): 1011-1033;
Structure, Function and Evolution of Coronavirus Spike Proteins, Annual Reviews Virology 2016 Sep 29; 3(1): 237-261;
Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells in Vitro, PLoS 2009; 4(11): e7870;
Pattern Recognition Receptors, Interferon pathways and cytokine cascades
Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage, Clinical and Experimental Immunology, Journal of Translational Immunology, 26 September 2020;
Pulmonary vascular (right ventricular) consequences of COVID-19
Novel insights on the pulmonary vascular consequences of COVID-19, Lung Cellular and Molecular Physiology 2020 Aug 1; 319(2): L277-288;
Sepsis
Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular thrombotic disease, Thrombosis Journal 2019; 17: 10;
Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS, Pulmonary Circulation 2018 Apr-Jun; 8(2);
Therapeutics and possible treatment options for COVID-19
Oxytocin as a Potential Adjuvant against COVID-19 Infection, Endocrine, Metabolic & Immune Disorders Drug Targets 2020, Sep 10;
Prophylactic efficacy of Quercetin in ameliorating the hypoxia induced vascular leakage in lungs of rats, PLoS One 2019; 14(6);
Nifedipine inhibits hypoxia induced transvascular leakage through downregulation of NFkB, Respiratory Physiology & Neurobiology Vol. 183, Issue 1, 31 July 2012, p26-34;
