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| Factors involved in SARS-CoV-2/ COVID-19 |
Autophages
Autophagy markers as mediators of lung injury-implication for therapeutic intervention, Life Science 2020 Nov 1; 260: 118308;
Autophagy augmentation to alleviate immune response dysfunction and resolve respiratory and COVID-19 exacerbations, MDPI Cells 2020, 9(9), 1952;
Cardiovascular disease caused by SARS-CoV-2
Potential Effects of Coronaviruses on the Cardiovascular System: A Review, JAMA Cardiology 2020;5(7):831-840;
Cardiac dysfunction and thrombocytopenia-associated multiple organ failure inflammation phenotype in a severe paediatric case of COVID-19, Lancet Child & Adolescent Health Vol. 4, Issue 7, p552-554, July 01, 2020;
ACE2 down-regulation may contribute to the increased thrombotic risk in COVID-19, European Heart Journal Vol. 41, Issue 33, 1 September 2020;
Coagulation
The unique characteristics of COVID-19 coagulopathy, Critical Care 2020; 24: 360;
Hypercoagulation and Antithrombotic Treatment in Coronavirus 2019: A new Challenge, Thrombosis and Haemostasis Vol. 120, Issue 6, June 2020, p949-956;
Coagulation abnormalities and thrombosis in patients with COVID-19, Lancet Haematology 2020 Jun; 7(6): e438-440;
COVID-19 coagulopathy vs Disseminated Intravascular Coagulation (DIC), Blood Advances 2020, Jun 23; 4(12): 2850;
Viral Coagulopathy in Patients With COVID-19: Treatment and Care, Clinical and Applied Thrombosis/Hemostasis 2020 Jan-Dec; 26;
Procoagulatio, hypercoagulatio és fibrinolysis "shut down" detected with ClotPro viscoelastic tests in COVID-19 patients, Orvosi Hetilap Vol. 161, Issue 22, 01 May 2020;
Thromboelastic Results and Hypercoagulability Syndrome in Patients With COVID-19 Who Are Critically Ill, JAMA Infectious Diseases 2020; 3(6);
Comparative pathogenesis
Comparative pathogenesis of COVID-19, MERS, and SARS (2003) in a nonhuman primate model, AAAS 2020 May 29; 368(6494): 1012-1015;
Emergence and molecular mechanisms of SARS-CoV-2 and HIV to target host cells and potential therapeutics, Infection, Genetics and Evolution 2020 Oct. 6: 104583;
Cytokine cascade
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines, Open Biology 2020 Sep; 10(9): 200160;
Fibroblasts
Fibroblasts and Their Pathological Functions in the Fibrosis of Aortic Valve Sclerosis and Atherosclerosis, Journal of Biomolecules 2019 Sep; 9(9): 427;
Hematology
Coronavirus Disease 2019 (COVID-19): A Haemotologist's Perspective, Acta Haematologica 2020, Jul 28: 1-14;
Hemostasis in COVID-19
Hemostasis profile in COVID-19, SciELO July 3, 2020;
Hyperinflammatory Syndrome (cHIS)
Clinical criteria for COVID-19 -associated hyperinflammatory syndrome (cHIS): a cohort study, Lancet Rheumatology, September 29, 2020;
Immunity and immunomodulation
Targeting the NLRP3 Inflammasome in Severe COVID-19, Frontiers in Immunology 2020; 11:1518;
Breadth of concomitant immune responses prior to patient recovery: a case report from non-severe COVID-19 (ASCs, Tfh, CD4+ and CD8+), Nature Medicine 2020 March 16: 1-3;
Interferons (IFN-x)
Evasion of type I Interferon by SARS-CoV-2, Cell Reports 2020 Oct 06; 33(1): 108234;
Interleukins (IL- )
Interleukin-1beta- A Friend or Foe in Malignancies?, International Journal of Molecular Science 2018 Aug; 19(8): 2155;
Transient expression of IL-1beta induces Acute Lung Injury and chronic repair leading to pulmonary fibrosis, Journal of Clinical Investigation 2001 Jun 15; 107(12): 1529-1536;
IL-6 trans-signaling induces PAI-1 from vascular endothelial cells in cytokine release syndrome, PNAS 2020 Sep 8; 117(36): 22351-22356;
Anti-Cytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Artherothrombosis, Journal of Circulation Research 2019 Feb; 124 (3): 537-450;
NLRP3 Inflammasome
SARS-CoV-2 infection and overactivation of NLRP3 inflammasome as a trigger of "cytokine storm" and risk factor for damage of hematopoietic cells, Leukemia 2020; 34(7): 1726-1729;
NLRP3 Inflammasome- A Key Player in Antiviral Responses, Frontiers in Immunology 2020; 11: 211;
Severe COVID-19: NLRP3 Inflammasome dysregulated, Frontiers in Immunology 2020; 11: 1580;
Nsp13, nsp14, nsp15
SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts, Virologica Sinica 2020 Jun; 35(3): 321-329;
SARS-CoV-2 nsp13, nsp14, nsp15 and ORF6 function as potent interferon antagonists, Emerging Microbes & Infections 2020; 9(1): 1418-1428;
Oxidative Stress (ROS) and shortage of antioxidants
Oxidative Stress as Key Player in SARS-CoV Infection, Archives of Medical Research 2020 Jul; 51(5): 384-387;
ORF-x protein of SARS-Coronavirus-2
SARS-CoV-2 nsp13, nsp14, nsp15 and ORF6 function as potent interferon antagonists, Emerging Microbes & Infections 2020; 9(1): 1418-1428;
SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant, Immunology Network (preprint available from BioRxiv), May 12, 2020;
Pathogenesis and structure of SARS-CoV-2
Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression, Journal of Physiology Vol. 35, Issue 5, September 2020, p288-301;
Beyond shielding: the roles of glycans in the SARS-CoV-2 Spike Protein, ACS Cent. Sci. 2020, September 23, 2020;
Differential expression of ACE2 in the respiratory tracts and its relationship to COVID-19 pathogenesis, EBioMedicine Vol. 60, Issue 103004, October 01, 2020;
Platelets
Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (COVID-19), Platelets Journal Vol. 31, Issue 5, 2020;
Platelet Activation is Associated With Myocardial Infarction in Patients With Pneumonia, Journal of the American College of Cardiology Vol. 64, Issue 18, 4 November 2014, P1917-1925;
RNA Sequence and establishing the gold standard in RT-PCR
The establishment of reference sequence for SARS-CoV-2 and variation analysis, Journal of Medical Virology Vol. 92, Issue 6, June 2020, p667-674;
False-positive COVID-19 results: hidden problems and costs (false-positives estimated between 0,8 and 4%), Lancet Respiratory Medicine, September29, 2020;
Sepsis
SARS-CoV-2 and viral sepsis: observations and hypotheses, Lancet Hypothesis Vol. 395, Issue 10235, P1517-1520, May 09, 2020;
T-cell profile
Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19 (cytokine storms marked by more nonfunctional CD4+ T cells and higher senescent CD8+ T cells), Clinical Immunology 2020 Jul; 216: 108464;
Thrombotic Thrombocytopenic Purpura (TTP)
Immune thrombocytopenic purpura after COVID-19 infection, International Journal of Laboratory Hematology 2020, Sep 20: 10.1111;
Treatment options
Is Antioxidant Therapy a Useful Complementary Measure for COVID-19 Treatment? An Algorithm for its Application, Medicina Kaunas 2020 Aug; 56(8): 386;
Kaempferol Alleviates the Interleukin-1beta-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-kB, Medical Science Monitor 2017; 23: 3925-3931;
Possible effect op epinephrine in minimizing COVID-19 severity: a review, Journal of International Medical Research 2020 Sep; 48(9);
Early outcomes with utilization of tPA (tissue plasminogen activator) in COVID-19-associated respiratory distress (ARDS): A series of five cases, Journal of Trauma and Acute Care Surgery: September 2020, Vol. 89, Issue 3, p448-452;
CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement, Stem Cell Reviews and Reports 2020 Apr 20: 1-7;
Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation CD147, Molecular Biology Reports 2020 Sep 12: 1-5;
ADAMTS13: An Emerging Target in Stroke Therapy, Frontiers in Neurology, 17 July 2019;
The Potential Impact of Zinc Supplementation on COVID-19, Frontiers Nutritional Immunology, 10 July 2020;
B cell activation and proliferation increase intracellular zinc levels, Journal of Nutritional Biochemistry 2019 Feb; 64: 72-79;
Urokinase
Early outcomes with utilization of tPA (tissue plasminogen activator) in COVID-19-associated respiratory distress (ARDS): A series of five cases, Journal of Trauma and Acute Care Surgery: September 2020, Vol. 89, Issue 3, p448-452;
